Sign In | Join Free | My lorrytrans.com
lorrytrans.com
Products
Search by Category
Home > Chemical Machinery >

Chloroquine Phosphate Tablets 150mg, 250mg, 500mg Oral Medications Antimalarial Medication

Categories Oral Medications
Brand Name: Newlystar
Place of Origin: China
MOQ: Tow million tablets
Payment Terms: L/C, T/T
Delivery Time: 45days
Packaging Details: 10’s/blister
Model Number: 150mg, 250mg, 500mg
Certification: GMP
Price: Negotiation
Supply Ability: One million pills per day
Product: Chloroquine Phosphate Tablets
Specification: 150mg, 250mg, 500mg
Standard: BP, USP
Packing: 10’s/blister
  • Haven't found right suppliers
  • Our buyer assistants can help you find the most suitable, 100% reliable suppliers from China.
  • And this service is free of charge.
  • we have buyer assistants who speak English, French, Spanish......and we are ready to help you anytime!
  • Submit Buying Request
    • Product Details
    • Company Profile

    Chloroquine Phosphate Tablets 150mg, 250mg, 500mg Oral Medications Antimalarial Medication

    Chloroquine Phosphate Tablets 150mg, 250mg, 500mg Oral Medications Antimalarial Medication


    Product : Chloroquine Phosphate Tablets

    Specification : 150mg, 250mg, 500mg

    Standard : BP, USP

    Packing : 10’s/blister


    Description :

    The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.


    Indication :

    For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis


    Pharmacodynamics :

    Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It is highly effective against erythrocytic forms of Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, sensitive strains of Plasmodium falciparum and gametocytes of Plasmodium vivax. Being alkaline, the drug reaches high concentration within the food vacuoles of the parasite and raises its pH. It is found to induce rapid clumping of the pigment. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids.


    Mechanism of action :

    The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. nside red blood cells, the malarial parasite must degrade hemoglobin to acquire essential amino acids, which the parasite requires to construct its own protein and for energy metabolism. Digestion is carried out in a vacuole of the parasite cell. During this process, the parasite produces the toxic and soluble molecule heme. The heme moiety consists of a porphyrin ring called Fe(II)-protoporphyrin IX (FP). To avoid destruction by this molecule, the parasite biocrystallizes heme to form hemozoin, a non-toxic molecule. Hemozoin collects in the digestive vacuole as insoluble crystals. Chloroquine enters the red blood cell, inhabiting parasite cell, and digestive vacuole by simple diffusion. Chloroquine then becomes protonated (to CQ2+), as the digestive vacuole is known to be acidic (pH 4.7); chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme (or FP) to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.

    Product Tags:

    Oral Preparation

      

    oral treatment

      
    Quality Chloroquine Phosphate Tablets 150mg, 250mg, 500mg Oral Medications Antimalarial Medication for sale
    Send your message to this supplier
     
    From:
    Enter your email please.
    To: Newlystar (Ningbo) Medtech Co.,Ltd.
    Subject:
    Message:
    Characters Remaining: (0/3000)
     
    Inquiry Cart 0

    Home| Products| Suppliers| Quality Suppliers| Site Map |About Us |Contact Us |Help |关于我们 |联系我们

    Copyright © 2009 - 2017 lorrytrans.com. All rights reserved.