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Diclofenac Sodium Injection Small Volume Parenteral 75mg/3ml analgesic anti-inflammatory

Categories Small Volume Parenteral
Brand Name: Newlystar
Place of Origin: China
MOQ: 300, 000 amps
Payment Terms: L/C, T/T
Delivery Time: 45days
Packaging Details: 10 x 10amps/box
Model Number: 75mg/3ml
Certification: GMP
Price: Negotiation
Supply Ability: one million amps per day
Product: Diclofenac Sodium Injection
Specification: 75mg/3ml
Standard: BP, USP
Packing: 10 x 10amps/box
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    Diclofenac Sodium Injection Small Volume Parenteral 75mg/3ml analgesic anti-inflammatory

    Diclofenac Sodium Injection Small Volume Parenteral 75mg/3ml analgesic anti-inflammatory


    Product : Diclofenac Sodium Injection

    Specification : 75mg/3ml

    Standard : BP, USP

    Packing : 10 x 10amps/box


    Description :

    Diclofenac sodium belongs to a class of medicines called non-steroidal anti-inflammatory drugs ( NSAIDs). Diclofenac sodium helps to reduce inflammation and to reduce pain. Diclofenac sodium works by blocking the production of some of the body chemicals that cause inflammation, pain, stiffness, tenderness, swelling and increased temperature.

    By reducing inflammation in conditions affecting muscles and joints Diclofenac sodium helps to increase strength and movement.


    Indication and Usage :

    Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs are prescribed for adults and the elderly for treatment of painful conditions, such as kidney stone pain,osteoarthritis (degeneration of joints) and rheumatoid arthritis (inflammation of joints), backpain, gout (formation of crystals in joints), injuries and fractures.


    Pharmacodynamics :

    Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis


    Mechanism of action :

    The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.


    Contraindications :

    Active GI bleeding or ulcers; asthma attacks, rhinitis, or urticaria from aspirin or other NSAIDs; hypersensitivity to diclofenac or NSAIDs; treatment of perioperative pain after coronary artery bypass grafting


    Interactions :

    Drugs :

    acetaminophen: Increased risk of adverse renal effects with long-term concurrent use anticoagulants, thrombolytics: Prolonged PT, increased risk of bleeding

    antihypertensives: Decreased anti-hypertensive effectiveness aspirin, other NSAIDs, salicylates: Increased GI irritability and bleeding, decreased diclofenac effectiveness

    beta blockers: Impaired antihypertensive effect

    cefamandole, cefoperazone, cefotetan, plicamycin, valproic acid: Increased risk of hypoprothrombinemia

    cimetidine: Altered blood diclofenac level colchicine, corticotropin (long-term use), glucocorticoids, potassium supplements: Increased GI irritability and bleeding cyclosporine, gold compounds, nephrotoxic drugs: Increased risk of nephrotoxicity CYP2C9 inducers such as rifampin: Decreased effectiveness of diclofenac CYP2C9 inhibitors such as voriconazole: Increased risk of diclofenac adverse reactions and toxicity digoxin: Increased blood digoxin level insulin, oral antidiabetics: Decreased effects of these drugs

    lithium: Increased risk of lithium toxicity loop diuretics: Decreased diuretic effects

    methotrexate: Increased risk of methotrexate toxicity

    phenytoin: Increased blood phenytoin level potassium-sparing diuretics: Increased risk

    of hyperkalemia

    probenecid: Increased diclofenac toxicity

    foods

    food: Delayed absorption of delayed-release tablets

    activities

    alcohol use: Increased risk of GI irritability and bleeding

    Product Tags:

    Small Volume Injection

      
    Quality Diclofenac Sodium Injection Small Volume Parenteral 75mg/3ml analgesic anti-inflammatory for sale
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